Searchable abstracts of presentations at key conferences in endocrinology

ea0038p415 | Steroids | SFEBES2015

Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland

Babot Gerard Ruiz , Hadjidemetriou Irene , Ajodha Sharon Jane , Taylor David , Taylor Norman , Guasti Leonardo

The adrenal cortex is the primary site of steroid synthesis, producing glucocorticoids under the control of the hypothalamic–pituitary axis and mineralocorticoids under the control of the renin–angiotensin system.Adrenal insufficiency, which can be life threatening, is cause by a number of adrenal disorders, and lifelong management of these patients with exogenous steroids can be challenging. No drug suitably mimics the diurnal pattern of corti...